The photobiomodulating (PBM)  effects of visible red and near infra-red non- ablative PBM laser therapy on cutaneous aging of the skin demonstrates increases in both fibroblast and keratinocyte cell numbers, by using photometric, cytometric and radiochemical methods it has been demonstrated that that the decrease or increase of cell growth depends on the applied wavelengths, the joule energy density and pulse sequences that are coded into the laser beams, that are distinct from the frequency of the wavelength of light and this external laser stimulation can induce phase transitions at a cell level to support various chemical and physiological reactions that are fundamental to the regenerative and healing processes within the biological system.

The demand for non-invasive treatment of facial wrinkles forms a major part of cosmetic dermatology and non-ablative lasers offer excellent results, without the down-time associated with thermal ablative laser’s such as the Co2 laser.

Non-ablative lasers (Ga-As & He Ne) initiate direct modulation of connective tissue metabolism and gene expression in human Fibroblast cells, that activates synthesis of collagen regeneration within   skin, which is also beneficial for treating chronic non healing wounds, pressure sores and leg ulcers (E. Mester 1973).